王晓英,朱柯蕙,高苏蒙
WANG Xiao-ying,ZHU Ke-hui,GAO Su-meng

• 1:东南大学公共卫生学院

摘要(Abstract)：

p53基因是迄今发现与人类恶性肿瘤相关性最高的基因,也是肿瘤细胞中基因变异频率最高的靶基因,50%的肿瘤患者中均发现p53基因有缺失或突变。目前,检测p53基因点突变的方法较多,大概分为3种类型,即直接法、间接法和生物传感技术。本文对上述3种突变检测技术的原理、方法及进展作一简要综述。
The deletion or mutation of p53 gene are found in 50% of patients with tumors.At present,the methods for detection of site-directed mutation of p53 gene include direct method,indirect method and biosense technique.This article reviews the principles,procedures and advances of the three methods.

关键词(KeyWords)： p53基因;基因突变;肿瘤;检测技术
p53 gene;Gene mutation;Tumor;Detection technology

Abstract:

Keywords:

基金项目(Foundation): 教育部博士点基金(20110092120055);; 大学生创新性实验项目(1210286104、T13422001)

作者(Author): 王晓英,朱柯蕙,高苏蒙
WANG Xiao-ying,ZHU Ke-hui,GAO Su-meng

DOI: 10.13200/j.cnki.cjb.001925

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