牛春阳,薛琳琳,计红,李士泽
NIU Chun-yang,XUE Lin-lin,JI Hong,LI Shi-ze

• 1:黑龙江八一农垦大学动物科技学院
• 2:黑龙江职业学院

摘要(Abstract)：

长链非编码RNA(long non-coding RNA,lncRNA)是缺乏开放阅读框架,长度约为200 nt～100 000 bp,且不编码蛋白质的转录本。lncRNA的表达受到发育调控,具有组织及细胞特异性。目前认为,lncRNA执行重要的生物学功能,涉及转录调控、细胞内物质运输和染色体重塑,参与细胞分化、生长发育、应激反应和疾病发生发展等多种生物学进程。本文在介绍lncRNA的特征、分类、调控机制的基础上,重点对lncRNA的生物学功能进行综述。
Long non-coding RNAs(lncRNA)are transcripts without open reading frames,which are generally 200 nt to100 kb in length and do not encode proteins. The expression of lncRNA is regulated by development and has tissue and cell specificities. It is currently believed that lncRNAs perform important biological functions involving various biological processes such as transcriptional regulation,intracellular trafficking of substances and chromosomal remodeling,and participate in cell differentiation,growth and development,stress response and disease development. On the basis of introducing the characteristics,classification and regulation mechanism of lncRNA,this paper reviews the biological function of lncRNA.

关键词(KeyWords)： 长链非编码RNA;转录调控;生物学功能
Long non-coding RNA(lncRNA);Transcriptional regulation;Biological function

Abstract:

Keywords:

基金项目(Foundation): 中国博士后科学基金资助(2017M611404);; 黑龙江省自然科学基金面上项目(C2015041);; 黑龙江八一农垦大学博士科研启动基金(XDB-2016-09)

作者(Author): 牛春阳,薛琳琳,计红,李士泽
NIU Chun-yang,XUE Lin-lin,JI Hong,LI Shi-ze

DOI: 10.13200/j.cnki.cjb.002477

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